Assay Detail
Binding
CHEMBL5361626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human P2X7 receptor expressed in 1321N1 cells by FLIPR assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 1321N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From lead to clinic: A review of the structural design of P2X7R antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.13 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407113 | — | — | 1 | 8.62 |
| CHEMBL5440534 | — | — | 1 | 8.52 |
| CHEMBL5416813 | — | — | 1 | 8.40 |
| CHEMBL5399698 | — | — | 1 | 8.24 |
| CHEMBL5411789 | — | — | 1 | 8.01 |
| CHEMBL5425082 | — | — | 1 | 7.00 |
| CHEMBL5419802 | — | — | 1 | - |
| CHEMBL5425149 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407113 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5440534 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5416813 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5399698 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5411789 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL5425082 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5419802 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL5425149 | — | IC50 | > | 100.0 | nM | - |