Assay Detail
Binding
CHEMBL5361840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus A/Goose/Guangdong/SH7/2013 (H5N1) neuraminidase using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as Fluorogenic substrate preincubated for 10 mins followed by substrate addition by fluorescence based microplate reader analysis
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 6.06 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.89 |
| CHEMBL5433425 | — | — | 1 | 7.51 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.35 |
| CHEMBL5430050 | — | — | 1 | 7.07 |
| CHEMBL5421602 | — | — | 1 | 7.00 |
| CHEMBL5398013 | — | — | 1 | 6.82 |
| CHEMBL5403839 | — | — | 1 | 6.57 |
| CHEMBL5425535 | — | — | 1 | 6.55 |
| CHEMBL3342478 | — | — | 1 | 6.51 |
| CHEMBL5439832 | — | — | 1 | 6.48 |
| CHEMBL5436445 | — | — | 1 | 6.44 |
| CHEMBL5393725 | — | — | 1 | 6.44 |
| CHEMBL5422976 | — | — | 1 | 6.43 |
| CHEMBL5422017 | — | — | 1 | 6.42 |
| CHEMBL5396566 | — | — | 1 | 6.38 |
| CHEMBL5432027 | — | — | 1 | 6.36 |
| CHEMBL5397365 | — | — | 1 | 6.26 |
| CHEMBL5408290 | — | — | 1 | 6.23 |
| CHEMBL5407760 | — | — | 1 | 6.12 |
| CHEMBL5416321 | — | — | 1 | 6.09 |
| CHEMBL5395436 | — | — | 1 | 5.94 |
| CHEMBL5418510 | — | — | 1 | 5.91 |
| CHEMBL5401942 | — | — | 1 | 5.91 |
| CHEMBL5423949 | — | — | 1 | 5.84 |
| CHEMBL5409472 | — | — | 1 | 5.83 |
| CHEMBL5404087 | — | — | 1 | 5.80 |
| CHEMBL5441084 | — | — | 1 | 5.78 |
| CHEMBL5395671 | — | — | 1 | 5.70 |
| CHEMBL5418356 | — | — | 1 | 5.64 |
| CHEMBL5434228 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5433425 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5430050 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5421602 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5398013 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5403839 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5425535 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3342478 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5439832 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5436445 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5393725 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5422976 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5422017 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5396566 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5432027 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5397365 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5408290 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5407760 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5416321 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5395436 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL5418510 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5401942 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5423949 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL5409472 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL5404087 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL5441084 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL5395671 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL5418356 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL5434228 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL5421351 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL5419945 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5440848 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL5396778 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL5435287 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL5439660 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL5426132 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5438370 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL5409653 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL5402900 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL5435946 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5429165 | — | IC50 | = | 12600.0 | nM | 4.90 |