Assay Detail
Binding
CHEMBL5361841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus A/Goose/Jiangsu/1306/2014 (H5N8) neuraminidase using 2(4-methylurnbellifery1)-a-u-acetyl neuraminic acid sodium salt hydrate (4-MUNANA) as Fluorogenic substrate preincubated for 10 mins followed by substrate addition by fluorescence based microplate reader analysis
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.99 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.48 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.17 |
| CHEMBL5433425 | — | — | 1 | 6.82 |
| CHEMBL5403839 | — | — | 1 | 6.54 |
| CHEMBL5407760 | — | — | 1 | 6.48 |
| CHEMBL5425535 | — | — | 1 | 6.43 |
| CHEMBL5398013 | — | — | 1 | 6.42 |
| CHEMBL5421602 | — | — | 1 | 6.41 |
| CHEMBL3342478 | — | — | 1 | 6.40 |
| CHEMBL5430050 | — | — | 1 | 6.29 |
| CHEMBL5422017 | — | — | 1 | 6.27 |
| CHEMBL5396566 | — | — | 1 | 6.23 |
| CHEMBL5422976 | — | — | 1 | 6.21 |
| CHEMBL5393725 | — | — | 1 | 6.19 |
| CHEMBL5416321 | — | — | 1 | 6.13 |
| CHEMBL5397365 | — | — | 1 | 6.11 |
| CHEMBL5418510 | — | — | 1 | 6.10 |
| CHEMBL5404087 | — | — | 1 | 6.10 |
| CHEMBL5396778 | — | — | 1 | 6.04 |
| CHEMBL5395436 | — | — | 1 | 6.00 |
| CHEMBL5439832 | — | — | 1 | 6.00 |
| CHEMBL5439660 | — | — | 1 | 5.99 |
| CHEMBL5408290 | — | — | 1 | 5.97 |
| CHEMBL5395671 | — | — | 1 | 5.96 |
| CHEMBL5409472 | — | — | 1 | 5.94 |
| CHEMBL5421351 | — | — | 1 | 5.93 |
| CHEMBL5401942 | — | — | 1 | 5.84 |
| CHEMBL5423949 | — | — | 1 | 5.76 |
| CHEMBL5432027 | — | — | 1 | 5.76 |
| CHEMBL5402900 | — | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5433425 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5403839 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5407760 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5425535 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5398013 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5421602 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL3342478 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5430050 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5422017 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5396566 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5422976 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5393725 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5416321 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5397365 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5418510 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5404087 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5396778 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5395436 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5439832 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5439660 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5408290 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5395671 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5409472 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5421351 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5401942 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL5423949 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL5432027 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL5402900 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL5436445 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL5426132 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL5419945 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL5440848 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5434228 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL5441084 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL5438370 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL5418356 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL5409653 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL5435287 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL5435946 | — | IC50 | = | 11620.0 | nM | 4.93 |
| CHEMBL5429165 | — | IC50 | = | 12090.0 | nM | 4.92 |