Assay Detail
Functional
CHEMBL5361845
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Anti-influenza virus activity against Influenza A virus A/Goose/Jiangsu/1306/2014 (H5N8) infected in chicken embryo fibroblast assessed as protection against virus-induced cytopathic effect incubated for 48 hrs by CCK-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.73 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5398013 | — | — | 1 | 6.16 |
| CHEMBL5433425 | — | — | 1 | 5.64 |
| CHEMBL5430050 | — | — | 1 | 5.59 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5398013 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5433425 | — | EC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL5430050 | — | EC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 2960.0 | nM | 5.53 |