Assay Detail
Functional
CHEMBL5361847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-influenza virus activity against Influenza A virus A/PuertoRico/8/1934 (H1N1) infected in dog MDCK cells assessed as reduction in viral plaque number incubated for 48 hrs by toluidine blue staining based plaque reduction assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.59 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 7.25 |
| CHEMBL5433425 | — | — | 1 | 6.70 |
| CHEMBL5398013 | — | — | 1 | 6.24 |
| CHEMBL5430050 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5433425 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5398013 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5430050 | — | EC50 | = | 660.0 | nM | 6.18 |