Assay Detail
Functional
CHEMBL5361848
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Anti-influenza virus activity against Influenza A virus A/WSN/67/05 (H3N2) infected in dog MDCK cells assessed as reduction in viral plaque number incubated for 48 hrs by toluidine blue staining based plaque reduction assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-substituted oseltamivir derivatives as novel neuraminidase inhibitors with improved drug resistance profiles and favorable drug-like properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.16 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 6.12 |
| CHEMBL5430050 | — | — | 1 | 5.13 |
| CHEMBL5433425 | — | — | 1 | 4.95 |
| CHEMBL5398013 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5430050 | — | EC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL5433425 | — | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL5398013 | — | EC50 | = | 35500.0 | nM | 4.45 |