Assay Detail
Functional
CHEMBL5361892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against multi-resistant Plasmodium falciparum W2 infected in erythrocytes assessed as inhibition of parasite growth incubated for 48 hrs by flow cytometry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Current development of β-carboline derived potential antimalarial scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.55 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289858 | — | — | 1 | 6.16 |
| CHEMBL5207836 | — | — | 1 | 5.96 |
| CHEMBL78448 | — | — | 1 | 5.96 |
| CHEMBL5203765 | — | — | 1 | 5.77 |
| CHEMBL5197622 | — | — | 1 | 5.41 |
| CHEMBL5081909 | — | — | 1 | 5.32 |
| CHEMBL5186379 | — | — | 1 | 5.16 |
| CHEMBL5184142 | — | — | 1 | 5.12 |
| CHEMBL241083 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289858 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5207836 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL78448 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5203765 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5197622 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5081909 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5186379 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL5184142 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL241083 | — | IC50 | = | 8100.0 | nM | 5.09 |