Assay Detail
Binding
CHEMBL5362137
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Binding affinity to MDMX (1 to 118 residues) (unknown origin) assessed as inhibition constant incubated for 1 hr measured by fluorescence polarization assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based discovery of novel α-aminoketone derivatives as dual p53-MDM2/MDMX inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.10 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3347643 | — | — | 1 | 6.11 |
| CHEMBL5418298 | — | — | 1 | 5.61 |
| CHEMBL5426939 | — | — | 1 | 5.46 |
| CHEMBL5416654 | — | — | 1 | 5.38 |
| CHEMBL5430787 | — | — | 1 | 5.13 |
| CHEMBL5437839 | — | — | 1 | 5.03 |
| CHEMBL5422731 | — | — | 1 | 4.94 |
| CHEMBL5400761 | — | — | 1 | 4.89 |
| CHEMBL5417713 | — | — | 1 | 4.88 |
| CHEMBL5433819 | — | — | 1 | 4.81 |
| CHEMBL5396791 | — | — | 1 | 4.54 |
| CHEMBL5400500 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3347643 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL5418298 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL5426939 | — | Ki | = | 3460.0 | nM | 5.46 |
| CHEMBL5416654 | — | Ki | = | 4220.0 | nM | 5.38 |
| CHEMBL5430787 | — | Ki | = | 7430.0 | nM | 5.13 |
| CHEMBL5437839 | — | Ki | = | 9370.0 | nM | 5.03 |
| CHEMBL5422731 | — | Ki | = | 11590.0 | nM | 4.94 |
| CHEMBL5400761 | — | Ki | = | 12930.0 | nM | 4.89 |
| CHEMBL5417713 | — | Ki | = | 13040.0 | nM | 4.88 |
| CHEMBL5433819 | — | Ki | = | 15570.0 | nM | 4.81 |
| CHEMBL5396791 | — | Ki | = | 29100.0 | nM | 4.54 |
| CHEMBL5400500 | — | Ki | = | 36820.0 | nM | 4.43 |