Assay Detail
Functional
CHEMBL5362138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116-p53-null cells overexpressing MDMX assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT116-p53-null |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based discovery of novel α-aminoketone derivatives as dual p53-MDM2/MDMX inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.61 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426939 | — | — | 1 | 4.87 |
| CHEMBL5418298 | — | — | 1 | 4.85 |
| CHEMBL5422731 | — | — | 1 | 4.81 |
| CHEMBL5416654 | — | — | 1 | 4.78 |
| CHEMBL5400500 | — | — | 1 | 4.76 |
| CHEMBL5400761 | — | — | 1 | 4.68 |
| CHEMBL5437839 | — | — | 1 | 4.68 |
| CHEMBL5396791 | — | — | 1 | 4.64 |
| CHEMBL5428948 | — | — | 1 | 4.58 |
| CHEMBL5430787 | — | — | 1 | 4.57 |
| CHEMBL5439641 | — | — | 1 | 4.55 |
| CHEMBL5417713 | — | — | 1 | 4.55 |
| CHEMBL2152332 | — | — | 1 | 4.53 |
| CHEMBL5409375 | — | — | 1 | 4.53 |
| CHEMBL5433819 | — | — | 1 | 4.52 |
| CHEMBL5418384 | — | — | 1 | 4.50 |
| CHEMBL5407048 | — | — | 1 | 4.49 |
| CHEMBL5394884 | — | — | 1 | 4.44 |
| CHEMBL5395339 | — | — | 1 | 4.43 |
| CHEMBL5413250 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426939 | — | IC50 | = | 13620.0 | nM | 4.87 |
| CHEMBL5418298 | — | IC50 | = | 14010.0 | nM | 4.85 |
| CHEMBL5422731 | — | IC50 | = | 15560.0 | nM | 4.81 |
| CHEMBL5416654 | — | IC50 | = | 16780.0 | nM | 4.78 |
| CHEMBL5400500 | — | IC50 | = | 17430.0 | nM | 4.76 |
| CHEMBL5400761 | — | IC50 | = | 20840.0 | nM | 4.68 |
| CHEMBL5437839 | — | IC50 | = | 20850.0 | nM | 4.68 |
| CHEMBL5396791 | — | IC50 | = | 23110.0 | nM | 4.64 |
| CHEMBL5428948 | — | IC50 | = | 26310.0 | nM | 4.58 |
| CHEMBL5430787 | — | IC50 | = | 26790.0 | nM | 4.57 |
| CHEMBL5439641 | — | IC50 | = | 28180.0 | nM | 4.55 |
| CHEMBL5417713 | — | IC50 | = | 28420.0 | nM | 4.55 |
| CHEMBL2152332 | — | IC50 | = | 29470.0 | nM | 4.53 |
| CHEMBL5409375 | — | IC50 | = | 29590.0 | nM | 4.53 |
| CHEMBL5433819 | — | IC50 | = | 30470.0 | nM | 4.52 |
| CHEMBL5418384 | — | IC50 | = | 31320.0 | nM | 4.50 |
| CHEMBL5407048 | — | IC50 | = | 32440.0 | nM | 4.49 |
| CHEMBL5394884 | — | IC50 | = | 36390.0 | nM | 4.44 |
| CHEMBL5395339 | — | IC50 | = | 37230.0 | nM | 4.43 |
| CHEMBL5413250 | — | IC50 | = | 37140.0 | nM | 4.43 |