Assay Detail
Binding
CHEMBL5362173
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Inhibition of PARP1 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An overview of compound properties, multiparameter optimization, and computational drug design methods for PARP-1 inhibitor drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.45 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5396891 | — | — | 1 | 10.64 |
| CHEMBL506871 | VELIPARIB | 3.0 | 1 | 10.21 |
| CHEMBL3137320 | TALAZOPARIB | 4.0 | 1 | 8.96 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 8.85 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 8.49 |
| CHEMBL4458889 | — | — | 1 | 7.89 |
| CHEMBL1094636 | NIRAPARIB | 4.0 | 1 | 7.78 |
| CHEMBL5274451 | — | — | 1 | 7.72 |
| CHEMBL4590570 | — | — | 1 | 7.72 |
| CHEMBL2347906 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5396891 | — | IC50 | = | 0.023 | nM | 10.64 |
| CHEMBL506871 | VELIPARIB | IC50 | = | 0.061 | nM | 10.21 |
| CHEMBL3137320 | TALAZOPARIB | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4458889 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1094636 | NIRAPARIB | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL5274451 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4590570 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2347906 | — | IC50 | = | 530.0 | nM | 6.28 |