Assay Detail
Functional
CHEMBL5362398
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Cytotoxicity against human HCT116-p53-null cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT116-p53-null |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.23 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.20 |
| CHEMBL5405897 | — | — | 1 | 5.67 |
| CHEMBL5407624 | — | — | 1 | 5.62 |
| CHEMBL5410712 | — | — | 1 | 5.51 |
| CHEMBL5417006 | — | — | 1 | 5.49 |
| CHEMBL5394765 | — | — | 1 | 5.42 |
| CHEMBL5399784 | — | — | 1 | 5.41 |
| CHEMBL5398539 | — | — | 1 | 5.27 |
| CHEMBL5437992 | — | — | 1 | 5.20 |
| CHEMBL5414253 | — | — | 1 | 5.05 |
| CHEMBL5415084 | — | — | 1 | 4.44 |
| CHEMBL5399747 | — | — | 1 | 4.38 |
| CHEMBL5413045 | — | — | 1 | 4.36 |
| CHEMBL5407930 | — | — | 1 | - |
| CHEMBL43612 | JUGLONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5405897 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5407624 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL5410712 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5417006 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL5394765 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL5399784 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL5398539 | — | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL5437992 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL5414253 | — | IC50 | = | 8830.0 | nM | 5.05 |
| CHEMBL5415084 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL5399747 | — | IC50 | = | 41690.0 | nM | 4.38 |
| CHEMBL5413045 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL5407930 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL43612 | JUGLONE | IC50 | - | — | - |