Assay Detail
Functional
CHEMBL5362400
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KB 3-1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB 3-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.26 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.25 |
| CHEMBL5407624 | — | — | 1 | 6.12 |
| CHEMBL5417006 | — | — | 1 | 6.06 |
| CHEMBL5394765 | — | — | 1 | 5.56 |
| CHEMBL5410712 | — | — | 1 | 5.48 |
| CHEMBL5399784 | — | — | 1 | 5.44 |
| CHEMBL5398539 | — | — | 1 | 5.34 |
| CHEMBL5437992 | — | — | 1 | 5.26 |
| CHEMBL5405897 | — | — | 1 | 5.16 |
| CHEMBL5414253 | — | — | 1 | 5.14 |
| CHEMBL5415084 | — | — | 1 | 4.63 |
| CHEMBL43612 | JUGLONE | — | 1 | 4.58 |
| CHEMBL5413045 | — | — | 1 | 4.33 |
| CHEMBL5399747 | — | — | 1 | 4.32 |
| CHEMBL5407930 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5407624 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5417006 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5394765 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL5410712 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL5399784 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL5398539 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL5437992 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL5405897 | — | IC50 | = | 6940.0 | nM | 5.16 |
| CHEMBL5414253 | — | IC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL5415084 | — | IC50 | = | 23380.0 | nM | 4.63 |
| CHEMBL43612 | JUGLONE | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL5413045 | — | IC50 | = | 46380.0 | nM | 4.33 |
| CHEMBL5399747 | — | IC50 | = | 47530.0 | nM | 4.32 |
| CHEMBL5407930 | — | IC50 | > | 50000.0 | nM | - |