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Assay Detail

CHEMBL5362402

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against mouse J774.2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Mus musculus
Cell Type J774.2
Confidence 1 — Organism
Curated By Autocuration

Target

J774.2 (CHEMBL614484)
Type CELL-LINE
Organism Mus musculus

Publication

Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone).
Ivasechko I, Lozynskyi A, Senkiv J, Roszczenko P, Kozak Y, Finiuk N, Klyuchivska O, Kashchak N, Manko N, Maslyak Z, Lesyk D, Karkhut A, Polovkovych S, Czarnomysy R, Szewczyk O, Kozytskiy A, Karpenko O, Khyluk D, Gzella A, Bielawski K, Bielawska A, Dzubak P, Gurska S, Hajduch M, Stoika R, Lesyk R.
Eur J Med Chem (2023) 252 : 115304 -115304
PubMed 37001390 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.26 6.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.25
CHEMBL5405897 1 6.08
CHEMBL5394765 1 5.69
CHEMBL5407624 1 5.59
CHEMBL5417006 1 5.53
CHEMBL5410712 1 5.28
CHEMBL5399784 1 5.28
CHEMBL5398539 1 5.17
CHEMBL5437992 1 5.17
CHEMBL5413045 1 5.13
CHEMBL43612 JUGLONE 1 4.87
CHEMBL5415084 1 4.58
CHEMBL5414253 1 4.57
CHEMBL5399747 1 4.51
CHEMBL5407930 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 560.0 nM 6.25
CHEMBL5405897 IC50 = 830.0 nM 6.08
CHEMBL5394765 IC50 = 2030.0 nM 5.69
CHEMBL5407624 IC50 = 2590.0 nM 5.59
CHEMBL5417006 IC50 = 2950.0 nM 5.53
CHEMBL5410712 IC50 = 5270.0 nM 5.28
CHEMBL5399784 IC50 = 5250.0 nM 5.28
CHEMBL5398539 IC50 = 6810.0 nM 5.17
CHEMBL5437992 IC50 = 6770.0 nM 5.17
CHEMBL5413045 IC50 = 7440.0 nM 5.13
CHEMBL43612 JUGLONE IC50 = 13360.0 nM 4.87
CHEMBL5415084 IC50 = 26390.0 nM 4.58
CHEMBL5414253 IC50 = 26890.0 nM 4.57
CHEMBL5399747 IC50 = 30830.0 nM 4.51
CHEMBL5407930 IC50 > 50000.0 nM -