Assay Detail

CHEMBL5362406

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Functional

Antileukemic activity against human CLL cell assessed as cell growth inhibition incubated for 72 hrs in presence of BST by MTT assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	CLL cell
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone).

Ivasechko I, Lozynskyi A, Senkiv J, Roszczenko P, Kozak Y, Finiuk N, Klyuchivska O, Kashchak N, Manko N, Maslyak Z, Lesyk D, Karkhut A, Polovkovych S, Czarnomysy R, Szewczyk O, Kozytskiy A, Karpenko O, Khyluk D, Gzella A, Bielawski K, Bielawska A, Dzubak P, Gurska S, Hajduch M, Stoika R, Lesyk R.
Eur J Med Chem (2023) 252 : 115304 -115304
PubMed 37001390 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.08	5.08

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5407624	—	—	1	5.08
CHEMBL53463	DOXORUBICIN	4.0	1	5.07

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5407624	—	IC50	=	8240.0	nM	5.08
CHEMBL53463	DOXORUBICIN	IC50	=	8600.0	nM	5.07