Assay Detail
Functional
CHEMBL5362598
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Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 5 days by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of fluorinated selective estrogen receptor degraders (FSERDs) --- A promising strategy for advanced ER positive breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.11 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 10.00 |
| CHEMBL5435635 | — | — | 1 | 7.26 |
| CHEMBL5399543 | — | — | 1 | 6.70 |
| CHEMBL5402320 | — | — | 1 | 6.55 |
| CHEMBL5416524 | — | — | 1 | 6.50 |
| CHEMBL5430365 | — | — | 1 | 6.47 |
| CHEMBL5409866 | — | — | 1 | 6.44 |
| CHEMBL5398675 | — | — | 1 | 6.43 |
| CHEMBL5427349 | — | — | 1 | 6.25 |
| CHEMBL5405428 | — | — | 1 | 6.17 |
| CHEMBL5407143 | — | — | 1 | 5.84 |
| CHEMBL5430380 | — | — | 1 | 5.82 |
| CHEMBL5402450 | — | — | 1 | 5.73 |
| CHEMBL5436901 | — | — | 1 | 5.67 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 5.63 |
| CHEMBL5431883 | — | — | 1 | 5.59 |
| CHEMBL5405977 | — | — | 1 | 5.42 |
| CHEMBL5414885 | — | — | 1 | 5.37 |
| CHEMBL5410360 | — | — | 1 | 5.32 |
| CHEMBL5411891 | — | — | 1 | 5.23 |
| CHEMBL5411119 | — | — | 1 | 5.07 |
| CHEMBL5404608 | — | — | 1 | 5.00 |
| CHEMBL5438989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5435635 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5399543 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5402320 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5416524 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5430365 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5409866 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5398675 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5427349 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5405428 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5407143 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL5430380 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL5402450 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL5436901 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL5431883 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL5405977 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL5414885 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL5410360 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL5411891 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL5411119 | — | IC50 | = | 8570.0 | nM | 5.07 |
| CHEMBL5404608 | — | IC50 | = | 9910.0 | nM | 5.00 |
| CHEMBL5438989 | — | IC50 | > | 20000.0 | nM | - |