Assay Detail
Functional
CHEMBL5362828
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Antiproliferative activity against human KM12 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KM12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.10 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 8.54 |
| CHEMBL5412694 | — | — | 1 | 8.01 |
| CHEMBL5402022 | — | — | 1 | 7.94 |
| CHEMBL5431992 | — | — | 1 | 7.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5412694 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL5402022 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL5431992 | — | IC50 | = | 12.4 | nM | 7.91 |