Assay Detail
Binding
CHEMBL5362931
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Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by DTNB based Ellman's method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and anti-Alzheimer potential of novel α-amino phosphonate derivatives and probing their molecular interaction mechanism with acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.38 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.88 |
| CHEMBL5433354 | — | — | 1 | 6.54 |
| CHEMBL5429003 | — | — | 1 | 6.53 |
| CHEMBL5402496 | — | — | 1 | 6.51 |
| CHEMBL5421943 | — | — | 1 | 6.50 |
| CHEMBL5407606 | — | — | 1 | 6.49 |
| CHEMBL5424767 | — | — | 1 | 6.47 |
| CHEMBL5407691 | — | — | 1 | 6.45 |
| CHEMBL5424712 | — | — | 1 | 6.44 |
| CHEMBL5426913 | — | — | 1 | 6.43 |
| CHEMBL5412970 | — | — | 1 | 6.42 |
| CHEMBL5433166 | — | — | 1 | 6.41 |
| CHEMBL5420040 | — | — | 1 | 6.38 |
| CHEMBL5405994 | — | — | 1 | 6.37 |
| CHEMBL5415911 | — | — | 1 | 6.33 |
| CHEMBL5405968 | — | — | 1 | 6.33 |
| CHEMBL5439155 | — | — | 1 | 6.31 |
| CHEMBL5430999 | — | — | 1 | 6.27 |
| CHEMBL5413480 | — | — | 1 | 6.25 |
| CHEMBL5422865 | — | — | 1 | 6.19 |
| CHEMBL5407235 | — | — | 1 | 6.17 |
| CHEMBL5416780 | — | — | 1 | 6.09 |
| CHEMBL5428540 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL5433354 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL5429003 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL5402496 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL5421943 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL5407606 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL5424767 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL5407691 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL5424712 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL5426913 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL5412970 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL5433166 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL5420040 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL5405994 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL5415911 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL5405968 | — | IC50 | = | 465.0 | nM | 6.33 |
| CHEMBL5439155 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL5430999 | — | IC50 | = | 532.0 | nM | 6.27 |
| CHEMBL5413480 | — | IC50 | = | 558.0 | nM | 6.25 |
| CHEMBL5422865 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL5407235 | — | IC50 | = | 669.0 | nM | 6.17 |
| CHEMBL5416780 | — | IC50 | = | 805.0 | nM | 6.09 |
| CHEMBL5428540 | — | IC50 | = | 921.0 | nM | 6.04 |