Assay Detail
Functional
CHEMBL5362956
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Antiproliferative activity against human MDA-MB-468 cells assessed inhibition of cell growth incubated for 72 hrs by CCK-8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrazolo[3,4-b]pyridine derivatives as novel and potent Mps1 inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.41 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.30 |
| CHEMBL4456085 | BAY-1217389 | 1.0 | 1 | 8.05 |
| CHEMBL5410634 | — | — | 1 | 6.66 |
| CHEMBL5410578 | — | — | 1 | 6.43 |
| CHEMBL5428851 | — | — | 1 | 6.18 |
| CHEMBL5417870 | — | — | 1 | 6.07 |
| CHEMBL5426709 | — | — | 1 | 6.00 |
| CHEMBL5397510 | — | — | 1 | 5.90 |
| CHEMBL2140523 | — | — | 1 | 5.68 |
| CHEMBL5408605 | — | — | 1 | 5.68 |
| CHEMBL5434294 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4456085 | BAY-1217389 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5410634 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL5410578 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL5428851 | — | IC50 | = | 663.0 | nM | 6.18 |
| CHEMBL5417870 | — | IC50 | = | 857.0 | nM | 6.07 |
| CHEMBL5426709 | — | IC50 | = | 1002.0 | nM | 6.00 |
| CHEMBL5397510 | — | IC50 | = | 1268.0 | nM | 5.90 |
| CHEMBL2140523 | — | IC50 | = | 2101.0 | nM | 5.68 |
| CHEMBL5408605 | — | IC50 | = | 2088.0 | nM | 5.68 |
| CHEMBL5434294 | — | IC50 | = | 2623.0 | nM | 5.58 |