Assay Detail
Functional
CHEMBL5363210
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Antimalarial activity against asynchronous chloroquine-resistant Plasmodium falciparum K1 assessed as parasite growth inhibition infected in erythrocytes incubated for 72 hrs by SYBR green dye based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of novel pyrrole-hydroxybutenolide hybrids as promising antiplasmodial and anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.59 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.30 |
| CHEMBL5414631 | — | — | 1 | 5.78 |
| CHEMBL486985 | — | — | 1 | 5.54 |
| CHEMBL5431282 | — | — | 1 | 5.41 |
| CHEMBL5397300 | — | — | 1 | 5.38 |
| CHEMBL5398099 | — | — | 1 | 5.37 |
| CHEMBL5423393 | — | — | 1 | 5.36 |
| CHEMBL1487 | ATORVASTATIN | 4.0 | 1 | - |
| CHEMBL5416547 | — | — | 1 | - |
| CHEMBL1173058 | MUCOCHLORIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5414631 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL486985 | — | IC50 | = | 2875.0 | nM | 5.54 |
| CHEMBL5431282 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL5397300 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL5398099 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL5423393 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL1487 | ATORVASTATIN | IC50 | > | 5000.0 | nM | - |
| CHEMBL5416547 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1173058 | MUCOCHLORIC ACID | IC50 | > | 5000.0 | nM | - |