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Assay Detail

CHEMBL5363602

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of p97 (unknown origin) ATPase activity by Biomol Green Reagent based microplate reader analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Transitional endoplasmic reticulum ATPase (CHEMBL1075145)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer.
LaPorte MG, Alverez C, Chatterley A, Kovaliov M, Carder EJ, Houghton MJ, Lim C, Miller ER, Samankumara LP, Liang M, Kerrigan K, Yue Z, Li S, Tomaino F, Wang F, Green N, Stott GM, Srivastava A, Chou TF, Wipf P, Huryn DM.
ACS Med Chem Lett (2023) 14 : 977 -985
PubMed 37465292 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 7.36 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5416704 1 8.10
CHEMBL5407869 1 8.01
CHEMBL5399073 1 7.96
CHEMBL5441034 1 7.92
CHEMBL5397160 1 7.82
CHEMBL5419713 1 7.77
CHEMBL2311578 1 7.70
CHEMBL5402777 1 7.70
CHEMBL5414510 1 7.68
CHEMBL5426088 1 7.64
CHEMBL5409286 1 7.54
CHEMBL5413736 1 7.50
CHEMBL5399688 1 7.47
CHEMBL5404554 1 7.46
CHEMBL5426808 1 7.40
CHEMBL5419453 1 7.39
CHEMBL5409495 1 7.36
CHEMBL5412023 1 7.33
CHEMBL5414204 1 7.26
CHEMBL5400436 1 7.22
CHEMBL5433131 1 7.13
CHEMBL5415233 1 6.82
CHEMBL5398304 1 6.52
CHEMBL5422339 1 6.50
CHEMBL5399682 1 6.34
CHEMBL5426923 1 5.70
CHEMBL5402921 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5416704 IC50 = 7.9 nM 8.10
CHEMBL5407869 IC50 = 9.7 nM 8.01
CHEMBL5399073 IC50 = 11.0 nM 7.96
CHEMBL5441034 IC50 = 12.0 nM 7.92
CHEMBL5397160 IC50 = 15.0 nM 7.82
CHEMBL5419713 IC50 = 17.0 nM 7.77
CHEMBL2311578 IC50 = 20.0 nM 7.70
CHEMBL5402777 IC50 = 20.0 nM 7.70
CHEMBL5414510 IC50 = 21.0 nM 7.68
CHEMBL5426088 IC50 = 23.0 nM 7.64
CHEMBL5409286 IC50 = 29.0 nM 7.54
CHEMBL5413736 IC50 = 32.0 nM 7.50
CHEMBL5399688 IC50 = 34.0 nM 7.47
CHEMBL5404554 IC50 = 35.0 nM 7.46
CHEMBL5426808 IC50 = 40.0 nM 7.40
CHEMBL5419453 IC50 = 41.0 nM 7.39
CHEMBL5409495 IC50 = 44.0 nM 7.36
CHEMBL5412023 IC50 = 47.0 nM 7.33
CHEMBL5414204 IC50 = 55.0 nM 7.26
CHEMBL5400436 IC50 = 60.0 nM 7.22
CHEMBL5433131 IC50 = 74.0 nM 7.13
CHEMBL5415233 IC50 = 150.0 nM 6.82
CHEMBL5398304 IC50 = 300.0 nM 6.52
CHEMBL5422339 IC50 = 320.0 nM 6.50
CHEMBL5399682 IC50 = 460.0 nM 6.34
CHEMBL5426923 IC50 = 2012.0 nM 5.70
CHEMBL5402921 IC50 > 6000.0 nM -