Assay Detail
Binding
CHEMBL5363603
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Inhibition of p97 in human HeLa cells expressing UbG76V-GFP/ODD-Luc assessed as accumulation of Ub-GFP incubated for 6 hrs by confocal microscopic analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transitional endoplasmic reticulum ATPase (CHEMBL1075145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 5.79 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5441034 | — | — | 1 | 6.64 |
| CHEMBL5416704 | — | — | 1 | 6.44 |
| CHEMBL5399073 | — | — | 1 | 6.44 |
| CHEMBL5407869 | — | — | 1 | 6.19 |
| CHEMBL5426088 | — | — | 1 | 6.09 |
| CHEMBL5402777 | — | — | 1 | 6.09 |
| CHEMBL5414510 | — | — | 1 | 6.05 |
| CHEMBL5399688 | — | — | 1 | 6.03 |
| CHEMBL5419713 | — | — | 1 | 5.89 |
| CHEMBL5426808 | — | — | 1 | 5.89 |
| CHEMBL5419453 | — | — | 1 | 5.82 |
| CHEMBL5409286 | — | — | 1 | 5.75 |
| CHEMBL2311578 | — | — | 1 | 5.75 |
| CHEMBL5413736 | — | — | 1 | 5.72 |
| CHEMBL5400436 | — | — | 1 | 5.62 |
| CHEMBL5412023 | — | — | 1 | 5.60 |
| CHEMBL5397160 | — | — | 1 | 5.57 |
| CHEMBL5404554 | — | — | 1 | 5.57 |
| CHEMBL5414204 | — | — | 1 | 5.57 |
| CHEMBL5409495 | — | — | 1 | 5.35 |
| CHEMBL5415233 | — | — | 1 | 4.96 |
| CHEMBL5399682 | — | — | 1 | 4.33 |
| CHEMBL5433131 | — | — | 1 | - |
| CHEMBL5398304 | — | — | 1 | - |
| CHEMBL5422339 | — | — | 1 | - |
| CHEMBL5402921 | — | — | 1 | - |
| CHEMBL5426923 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5441034 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5416704 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5399073 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5407869 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5426088 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5402777 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5414510 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5399688 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5419713 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5426808 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5419453 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5409286 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2311578 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5413736 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5400436 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5412023 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5397160 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5404554 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5414204 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5409495 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5415233 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5399682 | — | EC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL5433131 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL5398304 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL5422339 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL5402921 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL5426923 | — | EC50 | > | 40000.0 | nM | - |