Assay Detail
Binding
CHEMBL5363630
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Inhibition of human DGK gamma using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.79 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5424446 | — | — | 1 | 6.17 |
| CHEMBL5408449 | — | — | 1 | 5.72 |
| CHEMBL261131 | DIACYLGLYCEROL KINASE INHIBITOR II | — | 1 | 5.47 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5424446 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5408449 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL261131 | DIACYLGLYCEROL KINASE INHIBITOR II | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL267777 | RITANSERIN | IC50 | > | 10000.0 | nM | - |