Assay Detail
Functional
CHEMBL5363646
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Antiproliferative activity against human CD8-positive T cell measured after 24 hrs by Cell titer glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CD8-positive T cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.19 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5424446 | — | — | 1 | 7.19 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | - |
| CHEMBL261131 | DIACYLGLYCEROL KINASE INHIBITOR II | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5424446 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL267777 | RITANSERIN | EC50 | > | 10000.0 | nM | - |
| CHEMBL261131 | DIACYLGLYCEROL KINASE INHIBITOR II | EC50 | > | 10000.0 | nM | - |