Assay Detail
Binding
CHEMBL5364102
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal Avi-tagged and C-terminal His6-tagged USP3 (1 to 131 residues) (unknown origin) expressed in Escherichia coli BirA assessed as dissociation constant by SPR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ubiquitin carboxyl-terminal hydrolase 3 (CHEMBL5291515) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 4.65 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410606 | — | — | 1 | 4.96 |
| CHEMBL5426708 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410606 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL5426708 | — | Kd | = | 47000.0 | nM | 4.33 |