Assay Detail
Binding
CHEMBL5364103
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Binding affinity to N-terminal His-tagged HDAC6 UBD (1109 to 1213 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using N-terminal FITC-labeled LRLRGG as substrate by fluorescence polarization assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 24 | 5.75 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410606 | — | — | 1 | 7.02 |
| CHEMBL5428090 | — | — | 1 | 6.75 |
| CHEMBL5426586 | — | — | 1 | 6.66 |
| CHEMBL5406492 | — | — | 1 | 6.64 |
| CHEMBL5402254 | — | — | 1 | 6.62 |
| CHEMBL5402050 | — | — | 1 | 6.54 |
| CHEMBL5409340 | — | — | 1 | 6.50 |
| CHEMBL5409494 | — | — | 1 | 6.50 |
| CHEMBL5427723 | — | — | 1 | 6.26 |
| CHEMBL5430040 | — | — | 1 | 6.21 |
| CHEMBL5412490 | — | — | 1 | 5.80 |
| CHEMBL5424155 | — | — | 1 | 5.70 |
| CHEMBL5401898 | — | — | 1 | 5.70 |
| CHEMBL5437248 | — | — | 1 | 5.29 |
| CHEMBL5412794 | — | — | 1 | 5.29 |
| CHEMBL5431399 | — | — | 1 | 5.09 |
| CHEMBL5439441 | — | — | 1 | 5.04 |
| CHEMBL5401737 | — | — | 1 | 5.04 |
| CHEMBL5410297 | — | — | 1 | 5.03 |
| CHEMBL5433542 | — | — | 1 | 5.03 |
| CHEMBL5393985 | — | — | 1 | 5.02 |
| CHEMBL5430203 | — | — | 1 | 4.96 |
| CHEMBL5420153 | — | — | 1 | 4.85 |
| CHEMBL5426708 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410606 | — | Kd | = | 95.0 | nM | 7.02 |
| CHEMBL5428090 | — | Kd | = | 180.0 | nM | 6.75 |
| CHEMBL5426586 | — | Kd | = | 220.0 | nM | 6.66 |
| CHEMBL5406492 | — | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL5402254 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL5402050 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL5409340 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL5409494 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL5427723 | — | Kd | = | 550.0 | nM | 6.26 |
| CHEMBL5430040 | — | Kd | = | 620.0 | nM | 6.21 |
| CHEMBL5412490 | — | Kd | = | 1600.0 | nM | 5.80 |
| CHEMBL5424155 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL5401898 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL5437248 | — | Kd | = | 5100.0 | nM | 5.29 |
| CHEMBL5412794 | — | Kd | = | 5100.0 | nM | 5.29 |
| CHEMBL5431399 | — | Kd | = | 8100.0 | nM | 5.09 |
| CHEMBL5439441 | — | Kd | = | 9100.0 | nM | 5.04 |
| CHEMBL5401737 | — | Kd | = | 9100.0 | nM | 5.04 |
| CHEMBL5410297 | — | Kd | = | 9300.0 | nM | 5.03 |
| CHEMBL5433542 | — | Kd | = | 9400.0 | nM | 5.03 |
| CHEMBL5393985 | — | Kd | = | 9600.0 | nM | 5.02 |
| CHEMBL5430203 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL5420153 | — | Kd | = | 14000.0 | nM | 4.85 |
| CHEMBL5426708 | — | Kd | = | 33000.0 | nM | 4.48 |