Assay Detail
Binding
CHEMBL5364128
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at N-terminal NanoLuc-tagged USP16 R84A/Y117A mutant (unknown origin)/N-terminal HaloTag-tagged ISGI5 (unknown origin ) transfected in human HEK293T cells assessed as inhibition of protein-protein interaction preincubated for 240 min followed by Nano-Glo substrate addition and measured for 10 mins by NanoBRET assay
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 4.70 | 4.70 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410606 | — | — | 1 | 4.70 |
| CHEMBL5426708 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410606 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5426708 | — | Activity | - | — | - |