Assay Detail
Binding
CHEMBL5364256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal his6-tagged-thioredoxin-tagged human recombinant JMJD5 expressed in Escherichia coli using RPS6 as substrate by SPE-MS analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional peptidase and arginyl-hydroxylase JMJD5 (CHEMBL4523396) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.13 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419332 | — | — | 1 | 6.52 |
| CHEMBL5425339 | — | — | 1 | 6.40 |
| CHEMBL5408048 | — | — | 1 | 6.40 |
| CHEMBL5396670 | — | — | 1 | 6.40 |
| CHEMBL5407378 | — | — | 1 | 6.30 |
| CHEMBL5423565 | — | — | 1 | 6.16 |
| CHEMBL5428941 | — | — | 1 | 6.16 |
| CHEMBL5408058 | — | — | 1 | 6.16 |
| CHEMBL5402035 | — | — | 1 | 6.05 |
| CHEMBL5434665 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419332 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5425339 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5408048 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5396670 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5407378 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5423565 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5428941 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5408058 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5402035 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5434665 | — | IC50 | = | 17500.0 | nM | 4.76 |