Assay Detail
Binding
CHEMBL5364264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal his6-tagged FIH (unknown origin) expressed in Escherichia coli using HIF-alpha CAD (788 to 822 residues) expressed in Escherichia coli by SPE-MS analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.58 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423565 | — | — | 1 | 5.01 |
| CHEMBL5425339 | — | — | 1 | 4.61 |
| CHEMBL5419332 | — | — | 1 | 4.59 |
| CHEMBL5407378 | — | — | 1 | 4.54 |
| CHEMBL5402035 | — | — | 1 | 4.53 |
| CHEMBL5408048 | — | — | 1 | 4.50 |
| CHEMBL5396670 | — | — | 1 | 4.50 |
| CHEMBL5434665 | — | — | 1 | 4.47 |
| CHEMBL5428941 | — | — | 1 | 4.44 |
| CHEMBL5408058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423565 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5425339 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL5419332 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL5407378 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL5402035 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL5408048 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL5396670 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL5434665 | — | IC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL5428941 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL5408058 | — | IC50 | > | 50000.0 | nM | - |