Assay Detail
Binding
CHEMBL5364267
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal his6-tagged RIOX2 (26 to 465 residues) (unknown origin) expressed in Escherichia coli using RPL27A (31 to 49 residues) as substrate by SPE-MS analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.55 | 4.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5425339 | — | — | 1 | 4.61 |
| CHEMBL5419332 | — | — | 1 | 4.58 |
| CHEMBL5402035 | — | — | 1 | 4.56 |
| CHEMBL5407378 | — | — | 1 | 4.56 |
| CHEMBL5396670 | — | — | 1 | 4.56 |
| CHEMBL5434665 | — | — | 1 | 4.55 |
| CHEMBL5408048 | — | — | 1 | 4.48 |
| CHEMBL5423565 | — | — | 1 | 4.47 |
| CHEMBL5428941 | — | — | 1 | - |
| CHEMBL5408058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5425339 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL5419332 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL5402035 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL5407378 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL5396670 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL5434665 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL5408048 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL5423565 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL5428941 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5408058 | — | IC50 | > | 50000.0 | nM | - |