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Assay Detail

CHEMBL5364534

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human U2OS cells incubated for 2 hrs by cell titre blue viability assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U2OS
Confidence 1 — Organism
Curated By Autocuration

Target

U2OS (CHEMBL615023)
Type CELL-LINE
Organism Homo sapiens

Publication

Re-Exploring the Anthracycline Chemical Space for Better Anti-Cancer Compounds.
van Gelder MA, van der Zanden SY, Vriends MBL, Wagensveld RA, van der Marel GA, Codée JDC, Overkleeft HS, Wander DPA, Neefjes JJC.
J Med Chem (2023) 66 : 11390 -11398
PubMed 37561481 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.50 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4785287 1 7.96
CHEMBL5434379 1 7.92
CHEMBL1117 IDARUBICIN 4.0 1 7.62
CHEMBL3301909 1 7.25
CHEMBL178 DAUNORUBICIN 4.0 1 7.21
CHEMBL3303266 1 7.17
CHEMBL5407496 1 7.11
CHEMBL5407417 1 7.02
CHEMBL3302977 1 6.98
CHEMBL457065 1 6.93
CHEMBL5435610 1 6.91
CHEMBL5440084 1 6.80
CHEMBL502620 ACLARUBICIN 3.0 1 6.68
CHEMBL3249109 1 6.62
CHEMBL5405777 1 6.54
CHEMBL53463 DOXORUBICIN 4.0 1 6.47
CHEMBL5419503 1 6.42
CHEMBL3249110 13-DEOXYDOXORUBICIN 2.0 1 6.05
CHEMBL5396875 1 5.95
CHEMBL5424794 1 5.95
CHEMBL5409787 1 5.87
CHEMBL5426520 1 5.38
CHEMBL2074806 HYDROXYRUBICIN 1 5.17
CHEMBL5438238 1 5.00
CHEMBL5438617 1 5.00
CHEMBL3302568 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4785287 IC50 = 11.0 nM 7.96
CHEMBL5434379 IC50 = 12.0 nM 7.92
CHEMBL1117 IDARUBICIN IC50 = 24.0 nM 7.62
CHEMBL3301909 IC50 = 56.0 nM 7.25
CHEMBL178 DAUNORUBICIN IC50 = 61.0 nM 7.21
CHEMBL3303266 IC50 = 68.0 nM 7.17
CHEMBL5407496 IC50 = 77.0 nM 7.11
CHEMBL5407417 IC50 = 95.0 nM 7.02
CHEMBL3302977 IC50 = 105.0 nM 6.98
CHEMBL457065 IC50 = 118.0 nM 6.93
CHEMBL5435610 IC50 = 122.0 nM 6.91
CHEMBL5440084 IC50 = 159.0 nM 6.80
CHEMBL502620 ACLARUBICIN IC50 = 209.0 nM 6.68
CHEMBL3249109 IC50 = 237.0 nM 6.62
CHEMBL5405777 IC50 = 285.0 nM 6.54
CHEMBL53463 DOXORUBICIN IC50 = 339.0 nM 6.47
CHEMBL5419503 IC50 = 376.0 nM 6.42
CHEMBL3249110 13-DEOXYDOXORUBICIN IC50 = 891.0 nM 6.05
CHEMBL5396875 IC50 = 1121.0 nM 5.95
CHEMBL5424794 IC50 = 1126.0 nM 5.95
CHEMBL5409787 IC50 = 1362.0 nM 5.87
CHEMBL5426520 IC50 = 4208.0 nM 5.38
CHEMBL2074806 HYDROXYRUBICIN IC50 = 6793.0 nM 5.17
CHEMBL5438238 IC50 = 10000.0 nM 5.00
CHEMBL5438617 IC50 = 10000.0 nM 5.00
CHEMBL3302568 IC50 = 10000.0 nM 5.00