Assay Detail
Functional
CHEMBL5364592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 USA-WA1/2020 infected in Vero E6 cells assessed as reduction in viral plaque formation incubated for 3 days by plaque reduction neutralization assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.92 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399799 | — | — | 1 | 6.43 |
| CHEMBL5435470 | — | — | 1 | 6.43 |
| CHEMBL5438286 | — | — | 1 | 6.25 |
| CHEMBL5415290 | — | — | 1 | 6.12 |
| CHEMBL5425010 | — | — | 1 | 6.02 |
| CHEMBL5431050 | — | — | 1 | 5.89 |
| CHEMBL5276875 | — | — | 1 | 5.82 |
| CHEMBL3427141 | — | — | 1 | 5.58 |
| CHEMBL5398423 | — | — | 1 | 5.44 |
| CHEMBL3427168 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399799 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5435470 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5438286 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5415290 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5425010 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5431050 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5276875 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3427141 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5398423 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3427168 | — | EC50 | = | 6700.0 | nM | 5.17 |