Assay Detail
Binding
CHEMBL5364833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to JAK1 JH2 (unknown origin) assessed as dissociation constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress on the Pharmacological Targeting of Janus Pseudokinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.07 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | 9.64 |
| CHEMBL5424497 | — | — | 1 | 9.28 |
| CHEMBL5314423 | ZASOCITINIB | 3.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435170 | DEUCRAVACITINIB | Kd | = | 0.23 | nM | 9.64 |
| CHEMBL5424497 | — | Kd | = | 0.52 | nM | 9.28 |
| CHEMBL5314423 | ZASOCITINIB | Kd | = | 5000.0 | nM | 5.30 |