Assay Detail
Binding
CHEMBL5365098
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Antagonist activity at human P2X7 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Novel P2X7 Receptor Antagonists for the Treatment of Septic Acute Kidney Injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.47 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4159914 | — | — | 1 | 8.52 |
| CHEMBL4162056 | — | — | 1 | 8.28 |
| CHEMBL5394275 | — | — | 1 | 7.96 |
| CHEMBL3697519 | — | — | 1 | 7.88 |
| CHEMBL271462 | — | — | 1 | 7.80 |
| CHEMBL5221347 | — | — | 1 | 7.61 |
| CHEMBL5205239 | — | — | 1 | 7.47 |
| CHEMBL5425082 | — | — | 1 | 7.00 |
| CHEMBL5400871 | — | — | 1 | 6.99 |
| CHEMBL5440566 | — | — | 1 | 6.70 |
| CHEMBL5440646 | — | — | 1 | 5.96 |
| CHEMBL5411194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4159914 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4162056 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL5394275 | — | IC50 | = | 11.1 | nM | 7.96 |
| CHEMBL3697519 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL271462 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5221347 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL5205239 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5425082 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5400871 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5440566 | — | IC50 | = | 199.5 | nM | 6.70 |
| CHEMBL5440646 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5411194 | — | IC50 | < | 50.0 | nM | - |