Assay Detail
Binding
CHEMBL5365103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal 6His-tagged full length truncated SHMT1 (unknown origin) expressed in Escherichia coli Rosetta (DE3) pLysS assessed as inhibition constant by spectrophotometric analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine hydroxymethyltransferase, cytosolic (CHEMBL1772927) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 5.86 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438587 | — | — | 1 | 7.22 |
| CHEMBL5429283 | — | — | 1 | 6.92 |
| CHEMBL5440815 | — | — | 1 | 6.66 |
| CHEMBL5408906 | — | — | 1 | 6.10 |
| CHEMBL5431881 | — | — | 1 | 6.05 |
| CHEMBL5417651 | — | — | 1 | 5.98 |
| CHEMBL5402700 | — | — | 1 | 5.98 |
| CHEMBL5427804 | — | — | 1 | 5.96 |
| CHEMBL5405010 | — | — | 1 | 5.90 |
| CHEMBL5431331 | — | — | 1 | 5.82 |
| CHEMBL5421259 | — | — | 1 | 5.51 |
| CHEMBL5415985 | — | — | 1 | 5.15 |
| CHEMBL5418034 | — | — | 1 | 5.04 |
| CHEMBL5432700 | — | — | 1 | 4.88 |
| CHEMBL5400671 | — | — | 1 | 4.74 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
| CHEMBL1201746 | PRALATREXATE | 4.0 | 1 | - |
| CHEMBL225072 | PEMETREXED | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438587 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL5429283 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL5440815 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL5408906 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL5431881 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL5417651 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL5402700 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL5427804 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL5405010 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL5431331 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL5421259 | — | Ki | = | 3120.0 | nM | 5.51 |
| CHEMBL5415985 | — | Ki | = | 7100.0 | nM | 5.15 |
| CHEMBL5418034 | — | Ki | = | 9190.0 | nM | 5.04 |
| CHEMBL5432700 | — | Ki | = | 13270.0 | nM | 4.88 |
| CHEMBL5400671 | — | Ki | = | 18210.0 | nM | 4.74 |
| CHEMBL34259 | METHOTREXATE | Ki | > | 200000.0 | nM | - |
| CHEMBL1201746 | PRALATREXATE | Ki | > | 200000.0 | nM | - |
| CHEMBL225072 | PEMETREXED | Ki | > | 200000.0 | nM | - |