Assay Detail
Binding
CHEMBL5365319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DHODH using dihydroorotate and CoQ6 as substrate by DCIP dye based spectrophotometry analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.39 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405642 | — | — | 1 | 9.74 |
| CHEMBL5416427 | — | — | 1 | 9.42 |
| CHEMBL5409068 | — | — | 1 | 9.35 |
| CHEMBL5419814 | — | — | 1 | 9.29 |
| CHEMBL5434365 | — | — | 1 | 9.27 |
| CHEMBL5436904 | — | — | 1 | 9.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405642 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL5416427 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL5409068 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5419814 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL5434365 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL5436904 | — | IC50 | = | 0.57 | nM | 9.24 |