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Assay Detail

CHEMBL5365327

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Functional
Antiproliferative activity against ERalpha positive human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
ChEMBL ↗
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer.
Deng X, Deng X, Ning W, Xin L, Li Q, Hu Z, Xie B, Liang K, Min C, Dong C, Huang J, Zhou HB.
J Med Chem (2023) 66 : 11094 -11117
PubMed 37584263 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 55 6.16 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL107 COLCHICINE 4.0 1 9.00
CHEMBL5418245 — — 1 7.22
CHEMBL5437045 — — 1 7.05
CHEMBL1358 FULVESTRANT 4.0 1 6.92
CHEMBL5440184 — — 1 6.80
CHEMBL5410726 — — 1 6.77
CHEMBL5396802 — — 1 6.64
CHEMBL5404844 — — 1 6.60
CHEMBL5423453 — — 1 6.60
CHEMBL5414441 — — 1 6.60
CHEMBL5424737 — — 1 6.55
CHEMBL5425664 — — 1 6.55
CHEMBL5397595 — — 1 6.51
CHEMBL5425938 — — 1 6.50
CHEMBL5438152 — — 1 6.48
CHEMBL5440300 — — 1 6.46
CHEMBL5425101 — — 1 6.44
CHEMBL5425620 — — 1 6.38
CHEMBL5434346 — — 1 6.36
CHEMBL5397917 — — 1 6.36
CHEMBL5440727 — — 1 6.33
CHEMBL5408790 — — 1 6.31
CHEMBL5401690 — — 1 6.31
CHEMBL5394560 — — 1 6.24
CHEMBL5396545 — — 1 6.21
CHEMBL5397320 — — 1 6.18
CHEMBL489 AFIMOXIFENE 3.0 1 6.17
CHEMBL5407548 — — 1 6.16
CHEMBL5396353 — — 1 6.15
CHEMBL5428365 — — 1 6.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL107 COLCHICINE IC50 = 1.0 nM 9.00
CHEMBL5418245 — IC50 = 60.0 nM 7.22
CHEMBL5437045 — IC50 = 90.0 nM 7.05
CHEMBL1358 FULVESTRANT IC50 = 120.0 nM 6.92
CHEMBL5440184 — IC50 = 160.0 nM 6.80
CHEMBL5410726 — IC50 = 170.0 nM 6.77
CHEMBL5396802 — IC50 = 230.0 nM 6.64
CHEMBL5404844 — IC50 = 250.0 nM 6.60
CHEMBL5423453 — IC50 = 250.0 nM 6.60
CHEMBL5414441 — IC50 = 250.0 nM 6.60
CHEMBL5424737 — IC50 = 280.0 nM 6.55
CHEMBL5425664 — IC50 = 280.0 nM 6.55
CHEMBL5397595 — IC50 = 310.0 nM 6.51
CHEMBL5425938 — IC50 = 320.0 nM 6.50
CHEMBL5438152 — IC50 = 330.0 nM 6.48
CHEMBL5440300 — IC50 = 350.0 nM 6.46
CHEMBL5425101 — IC50 = 360.0 nM 6.44
CHEMBL5425620 — IC50 = 420.0 nM 6.38
CHEMBL5434346 — IC50 = 440.0 nM 6.36
CHEMBL5397917 — IC50 = 440.0 nM 6.36
CHEMBL5440727 — IC50 = 470.0 nM 6.33
CHEMBL5408790 — IC50 = 490.0 nM 6.31
CHEMBL5401690 — IC50 = 490.0 nM 6.31
CHEMBL5394560 — IC50 = 570.0 nM 6.24
CHEMBL5396545 — IC50 = 620.0 nM 6.21
CHEMBL5397320 — IC50 = 660.0 nM 6.18
CHEMBL489 AFIMOXIFENE IC50 = 670.0 nM 6.17
CHEMBL5407548 — IC50 = 700.0 nM 6.16
CHEMBL5396353 — IC50 = 710.0 nM 6.15
CHEMBL5428365 — IC50 = 780.0 nM 6.11
CHEMBL5416527 — IC50 = 860.0 nM 6.07
CHEMBL5416288 — IC50 = 1090.0 nM 5.96
CHEMBL5394327 — IC50 = 1180.0 nM 5.93
CHEMBL5420136 — IC50 = 1220.0 nM 5.91
CHEMBL5431311 — IC50 = 1230.0 nM 5.91
CHEMBL5419933 — IC50 = 1290.0 nM 5.89
CHEMBL5412552 — IC50 = 1320.0 nM 5.88
CHEMBL5394507 — IC50 = 1500.0 nM 5.82
CHEMBL5431315 — IC50 = 1630.0 nM 5.79
CHEMBL5430592 — IC50 = 1710.0 nM 5.77
CHEMBL5400731 — IC50 = 1850.0 nM 5.73
CHEMBL5434697 — IC50 = 1890.0 nM 5.72
CHEMBL5400134 — IC50 = 2020.0 nM 5.70
CHEMBL5394081 — IC50 = 2430.0 nM 5.61
CHEMBL5423157 — IC50 = 2490.0 nM 5.60
CHEMBL5418805 — IC50 = 2620.0 nM 5.58
CHEMBL5430579 — IC50 = 2750.0 nM 5.56
CHEMBL5408618 — IC50 = 2760.0 nM 5.56
CHEMBL5428020 — IC50 = 2810.0 nM 5.55
CHEMBL5438291 — IC50 = 2840.0 nM 5.55