Assay Detail
Toxicity
CHEMBL5365329
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 4.84 | 10.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 10.01 |
| CHEMBL1077183 | — | — | 1 | 5.65 |
| CHEMBL5397595 | — | — | 1 | 5.32 |
| CHEMBL5425938 | — | — | 1 | 5.13 |
| CHEMBL5401690 | — | — | 1 | 5.13 |
| CHEMBL5416527 | — | — | 1 | 5.12 |
| CHEMBL5424737 | — | — | 1 | 5.04 |
| CHEMBL5408790 | — | — | 1 | 4.99 |
| CHEMBL5396545 | — | — | 1 | 4.99 |
| CHEMBL5394507 | — | — | 1 | 4.98 |
| CHEMBL5399502 | — | — | 1 | 4.97 |
| CHEMBL5425101 | — | — | 1 | 4.96 |
| CHEMBL5394327 | — | — | 1 | 4.94 |
| CHEMBL5412552 | — | — | 1 | 4.93 |
| CHEMBL5410726 | — | — | 1 | 4.91 |
| CHEMBL5440300 | — | — | 1 | 4.89 |
| CHEMBL5418805 | — | — | 1 | 4.88 |
| CHEMBL5394081 | — | — | 1 | 4.86 |
| CHEMBL5425620 | — | — | 1 | 4.80 |
| CHEMBL5418245 | — | — | 1 | 4.80 |
| CHEMBL5438291 | — | — | 1 | 4.79 |
| CHEMBL5428365 | — | — | 1 | 4.76 |
| CHEMBL5440184 | — | — | 1 | 4.76 |
| CHEMBL5425664 | — | — | 1 | 4.75 |
| CHEMBL5414441 | — | — | 1 | 4.74 |
| CHEMBL5437045 | — | — | 1 | 4.74 |
| CHEMBL5400731 | — | — | 1 | 4.73 |
| CHEMBL5423157 | — | — | 1 | 4.70 |
| CHEMBL5396802 | — | — | 1 | 4.69 |
| CHEMBL5430592 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 0.098 | nM | 10.01 |
| CHEMBL1077183 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL5397595 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL5425938 | — | IC50 | = | 7490.0 | nM | 5.13 |
| CHEMBL5401690 | — | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL5416527 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL5424737 | — | IC50 | = | 9230.0 | nM | 5.04 |
| CHEMBL5408790 | — | IC50 | = | 10130.0 | nM | 4.99 |
| CHEMBL5396545 | — | IC50 | = | 10220.0 | nM | 4.99 |
| CHEMBL5394507 | — | IC50 | = | 10410.0 | nM | 4.98 |
| CHEMBL5399502 | — | IC50 | = | 10770.0 | nM | 4.97 |
| CHEMBL5425101 | — | IC50 | = | 11010.0 | nM | 4.96 |
| CHEMBL5394327 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL5412552 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL5410726 | — | IC50 | = | 12230.0 | nM | 4.91 |
| CHEMBL5440300 | — | IC50 | = | 12930.0 | nM | 4.89 |
| CHEMBL5418805 | — | IC50 | = | 13070.0 | nM | 4.88 |
| CHEMBL5394081 | — | IC50 | = | 13910.0 | nM | 4.86 |
| CHEMBL5425620 | — | IC50 | = | 15910.0 | nM | 4.80 |
| CHEMBL5418245 | — | IC50 | = | 15840.0 | nM | 4.80 |
| CHEMBL5438291 | — | IC50 | = | 16250.0 | nM | 4.79 |
| CHEMBL5428365 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL5440184 | — | IC50 | = | 17320.0 | nM | 4.76 |
| CHEMBL5425664 | — | IC50 | = | 17630.0 | nM | 4.75 |
| CHEMBL5437045 | — | IC50 | = | 18310.0 | nM | 4.74 |
| CHEMBL5414441 | — | IC50 | = | 18060.0 | nM | 4.74 |
| CHEMBL5400731 | — | IC50 | = | 18640.0 | nM | 4.73 |
| CHEMBL5423157 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL5396802 | — | IC50 | = | 20370.0 | nM | 4.69 |
| CHEMBL5430592 | — | IC50 | = | 20490.0 | nM | 4.69 |
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL5411516 | — | IC50 | = | 22570.0 | nM | 4.65 |
| CHEMBL5431311 | — | IC50 | = | 22730.0 | nM | 4.64 |
| CHEMBL5440727 | — | IC50 | = | 26850.0 | nM | 4.57 |
| CHEMBL5434346 | — | IC50 | = | 29170.0 | nM | 4.54 |
| CHEMBL5397320 | — | IC50 | = | 29780.0 | nM | 4.53 |
| CHEMBL5407548 | — | IC50 | = | 29680.0 | nM | 4.53 |
| CHEMBL5396353 | — | IC50 | = | 30210.0 | nM | 4.52 |
| CHEMBL5423453 | — | IC50 | = | 32410.0 | nM | 4.49 |
| CHEMBL5404844 | — | IC50 | = | 36690.0 | nM | 4.43 |
| CHEMBL5438152 | — | IC50 | = | 37870.0 | nM | 4.42 |
| CHEMBL5397917 | — | IC50 | = | 38210.0 | nM | 4.42 |
| CHEMBL5408618 | — | IC50 | = | 38590.0 | nM | 4.41 |
| CHEMBL5430579 | — | IC50 | = | 41150.0 | nM | 4.39 |
| CHEMBL5416288 | — | IC50 | = | 49080.0 | nM | 4.31 |
| CHEMBL5394560 | — | IC50 | = | 53630.0 | nM | 4.27 |
| CHEMBL5434697 | — | IC50 | = | 57620.0 | nM | 4.24 |
| CHEMBL5400134 | — | IC50 | = | 59930.0 | nM | 4.22 |
| CHEMBL5428020 | — | IC50 | = | 91460.0 | nM | 4.04 |
| CHEMBL5406235 | — | IC50 | > | 100000.0 | nM | - |