Assay Detail
Functional
CHEMBL5365734
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Antiproliferative activity against mouse Ba/F3 EGFR-Del19/T790M/C797S cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Ba/F3 EGFR-Del19/T790M/C797S |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of new pyrimidine derivatives as EGFR<sup>C797S</sup> tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.49 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5169450 | — | — | 1 | 9.80 |
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5169450 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 67.2 | nM | 7.17 |