Assay Detail
Functional
CHEMBL5366003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CXCR2 (unknown origin) expressed in HEK293 coexpressing snap-CXCR2-LGBit and beta-arrestin2-SMBit using furimazine as substrate preincubated for 1 hr followed by substrate addition and measured after 5 mins by bioluminescence based NanoBiT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.33 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216981 | NAVARIXIN ANHYDROUS | 2.0 | 1 | 8.54 |
| CHEMBL5421394 | — | — | 1 | 7.93 |
| CHEMBL5404638 | — | — | 1 | 7.54 |
| CHEMBL5423846 | — | — | 1 | 6.67 |
| CHEMBL5398802 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216981 | NAVARIXIN ANHYDROUS | IC50 | = | 2.884 | nM | 8.54 |
| CHEMBL5421394 | — | IC50 | = | 11.75 | nM | 7.93 |
| CHEMBL5404638 | — | IC50 | = | 28.84 | nM | 7.54 |
| CHEMBL5423846 | — | IC50 | = | 213.8 | nM | 6.67 |
| CHEMBL5398802 | — | IC50 | = | 1122.02 | nM | 5.95 |