Assay Detail
Binding
CHEMBL5366077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PRMT9 using biotinylated SF3B2(500 to 519 residues) as substrate and SAM as cosubstrate pre-incubated with compound for 30 mins followed by substrate addition measured after 60 mins by AlphaLISA assay
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 9 (CHEMBL4105724) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.81 | 6.70 |
| Inhibition | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5396270 | — | — | 1 | 6.70 |
| CHEMBL5199380 | — | — | 1 | 6.05 |
| CHEMBL5406557 | — | — | 1 | 5.99 |
| CHEMBL5202088 | — | — | 1 | 5.92 |
| CHEMBL5186617 | — | — | 1 | 5.89 |
| CHEMBL5170047 | — | — | 1 | 5.88 |
| CHEMBL5408585 | — | — | 1 | 5.61 |
| CHEMBL5206272 | — | — | 1 | 5.24 |
| CHEMBL5173678 | — | — | 1 | 5.03 |
| CHEMBL5191769 | — | — | 1 | - |
| CHEMBL2179359 | — | — | 1 | - |
| CHEMBL5426910 | — | — | 1 | - |
| CHEMBL2179350 | — | — | 1 | - |
| CHEMBL5394196 | — | — | 1 | - |
| CHEMBL5430799 | — | — | 1 | - |
| CHEMBL5420873 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5396270 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5199380 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5406557 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL5202088 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5186617 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5170047 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL5408585 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5206272 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL5173678 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5191769 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2179359 | — | Inhibition | - | % | - | |
| CHEMBL5426910 | — | Inhibition | - | % | - | |
| CHEMBL2179350 | — | Inhibition | - | % | - | |
| CHEMBL5394196 | — | Inhibition | - | % | - | |
| CHEMBL5430799 | — | Inhibition | - | % | - | |
| CHEMBL5420873 | — | Inhibition | - | % | - |