Assay Detail
Binding
CHEMBL5366126
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Inhibition of IMP-1 (unknown origin) expressed in Escherichia coli BL21-DE3 incubated for 15 mins by absorbance based microplate reader analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.68 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434080 | — | — | 1 | 6.62 |
| CHEMBL5434850 | — | — | 1 | 6.60 |
| CHEMBL5421999 | — | — | 1 | 6.43 |
| CHEMBL5408328 | — | — | 1 | 6.32 |
| CHEMBL5436058 | — | — | 1 | 6.16 |
| CHEMBL5397784 | — | — | 1 | 5.91 |
| CHEMBL5427511 | — | — | 1 | 5.28 |
| CHEMBL5439532 | — | — | 1 | 5.14 |
| CHEMBL5435754 | — | — | 1 | 5.09 |
| CHEMBL284104 | DIPICOLINIC ACID | — | 1 | 5.01 |
| CHEMBL1368601 | — | — | 1 | 4.99 |
| CHEMBL5265803 | — | — | 1 | 4.60 |
| CHEMBL5404428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434080 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5434850 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5421999 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5408328 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5436058 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5397784 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5427511 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL5439532 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL5435754 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL284104 | DIPICOLINIC ACID | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL1368601 | — | IC50 | = | 10320.0 | nM | 4.99 |
| CHEMBL5265803 | — | IC50 | = | 25160.0 | nM | 4.60 |
| CHEMBL5404428 | — | IC50 | = | 101640.0 | nM | - |