Assay Detail
Binding
CHEMBL5366129
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Inhibition of GIM1 (unknown origin) incubated for 15 mins by absorbance based microplate reader analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.44 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434850 | — | — | 1 | 6.31 |
| CHEMBL5421999 | — | — | 1 | 6.19 |
| CHEMBL5436058 | — | — | 1 | 6.19 |
| CHEMBL5408328 | — | — | 1 | 5.90 |
| CHEMBL5434080 | — | — | 1 | 5.82 |
| CHEMBL5397784 | — | — | 1 | 5.51 |
| CHEMBL1368601 | — | — | 1 | 5.13 |
| CHEMBL5427511 | — | — | 1 | 4.95 |
| CHEMBL284104 | DIPICOLINIC ACID | — | 1 | 4.81 |
| CHEMBL5435754 | — | — | 1 | 4.68 |
| CHEMBL5439532 | — | — | 1 | 4.30 |
| CHEMBL5404428 | — | — | 1 | - |
| CHEMBL5265803 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434850 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5421999 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5436058 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5408328 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL5434080 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5397784 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL1368601 | — | IC50 | = | 7380.0 | nM | 5.13 |
| CHEMBL5427511 | — | IC50 | = | 11210.0 | nM | 4.95 |
| CHEMBL284104 | DIPICOLINIC ACID | IC50 | = | 15610.0 | nM | 4.81 |
| CHEMBL5435754 | — | IC50 | = | 21090.0 | nM | 4.68 |
| CHEMBL5439532 | — | IC50 | = | 50060.0 | nM | 4.30 |
| CHEMBL5404428 | — | IC50 | - | — | - | |
| CHEMBL5265803 | — | IC50 | - | — | - |