Assay Detail
Binding
CHEMBL5366136
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Binding affinity to human recombinant MMP-2 CD assessed as inhibition constant using OMNIMMP as substrate incubated for 30 mins by fluorescence based analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.25 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434080 | — | — | 1 | 6.22 |
| CHEMBL5397784 | — | — | 1 | 5.67 |
| CHEMBL5439532 | — | — | 1 | 5.39 |
| CHEMBL5421999 | — | — | 1 | 5.24 |
| CHEMBL5434850 | — | — | 1 | 5.16 |
| CHEMBL5436058 | — | — | 1 | 5.11 |
| CHEMBL5405077 | — | — | 1 | 4.68 |
| CHEMBL5424619 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434080 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL5397784 | — | Ki | = | 2120.0 | nM | 5.67 |
| CHEMBL5439532 | — | Ki | = | 4080.0 | nM | 5.39 |
| CHEMBL5421999 | — | Ki | = | 5780.0 | nM | 5.24 |
| CHEMBL5434850 | — | Ki | = | 6920.0 | nM | 5.16 |
| CHEMBL5436058 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL5405077 | — | Ki | = | 20730.0 | nM | 4.68 |
| CHEMBL5424619 | — | Ki | = | 27630.0 | nM | 4.56 |