Assay Detail
Binding
CHEMBL5366245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SphK1 (unknown origin) using D-Sph as substrate incubated for 40 mins by ADP-Glo Plus luminescence kinase assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, antitumor activity, and molecular dynamics simulations of novel sphingosine kinase 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.33 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3134157 | — | — | 1 | 6.97 |
| CHEMBL4574678 | — | — | 1 | 6.35 |
| CHEMBL5420859 | — | — | 1 | 6.04 |
| CHEMBL5409737 | — | — | 1 | 6.03 |
| CHEMBL5412115 | — | — | 1 | 5.83 |
| CHEMBL5436330 | — | — | 1 | 5.11 |
| CHEMBL5396922 | — | — | 1 | 5.05 |
| CHEMBL5399307 | — | — | 1 | 4.75 |
| CHEMBL5407736 | — | — | 1 | 4.66 |
| CHEMBL5432322 | — | — | 1 | 4.52 |
| CHEMBL5424312 | — | — | 1 | 4.45 |
| CHEMBL5419726 | — | — | 1 | 4.18 |
| CHEMBL5407618 | — | — | 1 | - |
| CHEMBL5405542 | — | — | 1 | - |
| CHEMBL5433518 | — | — | 1 | - |
| CHEMBL5411043 | — | — | 1 | - |
| CHEMBL5421314 | — | — | 1 | - |
| CHEMBL5432767 | — | — | 1 | - |
| CHEMBL5414729 | — | — | 1 | - |
| CHEMBL5426621 | — | — | 1 | - |
| CHEMBL5416857 | — | — | 1 | - |
| CHEMBL5439990 | — | — | 1 | - |
| CHEMBL5408050 | — | — | 1 | - |
| CHEMBL5397765 | — | — | 1 | - |
| CHEMBL5407813 | — | — | 1 | - |
| CHEMBL5395822 | — | — | 1 | - |
| CHEMBL5419612 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3134157 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4574678 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL5420859 | — | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL5409737 | — | IC50 | = | 924.0 | nM | 6.03 |
| CHEMBL5412115 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5436330 | — | IC50 | = | 7763.0 | nM | 5.11 |
| CHEMBL5396922 | — | IC50 | = | 8963.0 | nM | 5.05 |
| CHEMBL5399307 | — | IC50 | = | 17680.0 | nM | 4.75 |
| CHEMBL5407736 | — | IC50 | = | 21850.0 | nM | 4.66 |
| CHEMBL5432322 | — | IC50 | = | 30430.0 | nM | 4.52 |
| CHEMBL5424312 | — | IC50 | = | 35650.0 | nM | 4.45 |
| CHEMBL5419726 | — | IC50 | = | 66220.0 | nM | 4.18 |
| CHEMBL5407618 | — | IC50 | - | — | - | |
| CHEMBL5405542 | — | IC50 | - | — | - | |
| CHEMBL5433518 | — | IC50 | - | — | - | |
| CHEMBL5411043 | — | IC50 | - | — | - | |
| CHEMBL5421314 | — | IC50 | - | — | - | |
| CHEMBL5432767 | — | IC50 | - | — | - | |
| CHEMBL5414729 | — | IC50 | - | — | - | |
| CHEMBL5426621 | — | IC50 | - | — | - | |
| CHEMBL5416857 | — | IC50 | - | — | - | |
| CHEMBL5439990 | — | IC50 | - | — | - | |
| CHEMBL5408050 | — | IC50 | - | — | - | |
| CHEMBL5397765 | — | IC50 | - | — | - | |
| CHEMBL5407813 | — | IC50 | - | — | - | |
| CHEMBL5395822 | — | IC50 | - | — | - | |
| CHEMBL5419612 | — | IC50 | - | — | - |