Assay Detail
Functional
CHEMBL5366247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, antitumor activity, and molecular dynamics simulations of novel sphingosine kinase 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.54 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414729 | — | — | 1 | 5.12 |
| CHEMBL5396922 | — | — | 1 | 5.07 |
| CHEMBL5407813 | — | — | 1 | 4.89 |
| CHEMBL3134157 | — | — | 1 | 4.79 |
| CHEMBL5409737 | — | — | 1 | 4.74 |
| CHEMBL5405542 | — | — | 1 | 4.69 |
| CHEMBL5399307 | — | — | 1 | 4.68 |
| CHEMBL5407618 | — | — | 1 | 4.67 |
| CHEMBL5407736 | — | — | 1 | 4.61 |
| CHEMBL5421314 | — | — | 1 | 4.51 |
| CHEMBL5424312 | — | — | 1 | 4.46 |
| CHEMBL5408050 | — | — | 1 | 4.40 |
| CHEMBL5397765 | — | — | 1 | 4.40 |
| CHEMBL5432322 | — | — | 1 | 4.37 |
| CHEMBL5436330 | — | — | 1 | 4.34 |
| CHEMBL5395822 | — | — | 1 | 4.29 |
| CHEMBL5412115 | — | — | 1 | 4.27 |
| CHEMBL5433518 | — | — | 1 | 4.27 |
| CHEMBL5432767 | — | — | 1 | 4.26 |
| CHEMBL5426621 | — | — | 1 | 4.26 |
| CHEMBL5439990 | — | — | 1 | 4.24 |
| CHEMBL5420859 | — | — | 1 | - |
| CHEMBL5416857 | — | — | 1 | - |
| CHEMBL4574678 | — | — | 1 | - |
| CHEMBL5419726 | — | — | 1 | - |
| CHEMBL5411043 | — | — | 1 | - |
| CHEMBL5419612 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414729 | — | IC50 | = | 7630.0 | nM | 5.12 |
| CHEMBL5396922 | — | IC50 | = | 8605.0 | nM | 5.07 |
| CHEMBL5407813 | — | IC50 | = | 12810.0 | nM | 4.89 |
| CHEMBL3134157 | — | IC50 | = | 16230.0 | nM | 4.79 |
| CHEMBL5409737 | — | IC50 | = | 18280.0 | nM | 4.74 |
| CHEMBL5405542 | — | IC50 | = | 20260.0 | nM | 4.69 |
| CHEMBL5399307 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL5407618 | — | IC50 | = | 21520.0 | nM | 4.67 |
| CHEMBL5407736 | — | IC50 | = | 24360.0 | nM | 4.61 |
| CHEMBL5421314 | — | IC50 | = | 30530.0 | nM | 4.51 |
| CHEMBL5424312 | — | IC50 | = | 34710.0 | nM | 4.46 |
| CHEMBL5408050 | — | IC50 | = | 39720.0 | nM | 4.40 |
| CHEMBL5397765 | — | IC50 | = | 39590.0 | nM | 4.40 |
| CHEMBL5432322 | — | IC50 | = | 42660.0 | nM | 4.37 |
| CHEMBL5436330 | — | IC50 | = | 45330.0 | nM | 4.34 |
| CHEMBL5395822 | — | IC50 | = | 51870.0 | nM | 4.29 |
| CHEMBL5412115 | — | IC50 | = | 53970.0 | nM | 4.27 |
| CHEMBL5433518 | — | IC50 | = | 53490.0 | nM | 4.27 |
| CHEMBL5432767 | — | IC50 | = | 55420.0 | nM | 4.26 |
| CHEMBL5426621 | — | IC50 | = | 55230.0 | nM | 4.26 |
| CHEMBL5439990 | — | IC50 | = | 58040.0 | nM | 4.24 |
| CHEMBL5420859 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5416857 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4574678 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5419726 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5411043 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5419612 | — | IC50 | > | 100000.0 | nM | - |