Assay Detail
Functional
CHEMBL5366248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human U-937 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, antitumor activity, and molecular dynamics simulations of novel sphingosine kinase 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.54 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436330 | — | — | 1 | 5.53 |
| CHEMBL5408050 | — | — | 1 | 5.07 |
| CHEMBL5432767 | — | — | 1 | 5.00 |
| CHEMBL5396922 | — | — | 1 | 4.76 |
| CHEMBL5426621 | — | — | 1 | 4.70 |
| CHEMBL5407736 | — | — | 1 | 4.59 |
| CHEMBL5407813 | — | — | 1 | 4.59 |
| CHEMBL5395822 | — | — | 1 | 4.53 |
| CHEMBL5411043 | — | — | 1 | 4.52 |
| CHEMBL5416857 | — | — | 1 | 4.51 |
| CHEMBL3134157 | — | — | 1 | 4.51 |
| CHEMBL5412115 | — | — | 1 | 4.50 |
| CHEMBL5405542 | — | — | 1 | 4.49 |
| CHEMBL5397765 | — | — | 1 | 4.48 |
| CHEMBL5424312 | — | — | 1 | 4.46 |
| CHEMBL5420859 | — | — | 1 | 4.42 |
| CHEMBL5409737 | — | — | 1 | 4.38 |
| CHEMBL5407618 | — | — | 1 | 4.36 |
| CHEMBL5419612 | — | — | 1 | 4.34 |
| CHEMBL5414729 | — | — | 1 | 4.32 |
| CHEMBL5433518 | — | — | 1 | 4.29 |
| CHEMBL5399307 | — | — | 1 | 4.29 |
| CHEMBL5439990 | — | — | 1 | 4.16 |
| CHEMBL5421314 | — | — | 1 | 4.16 |
| CHEMBL5432322 | — | — | 1 | - |
| CHEMBL4574678 | — | — | 1 | - |
| CHEMBL5419726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436330 | — | IC50 | = | 2951.0 | nM | 5.53 |
| CHEMBL5408050 | — | IC50 | = | 8436.0 | nM | 5.07 |
| CHEMBL5432767 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5396922 | — | IC50 | = | 17320.0 | nM | 4.76 |
| CHEMBL5426621 | — | IC50 | = | 20060.0 | nM | 4.70 |
| CHEMBL5407736 | — | IC50 | = | 25590.0 | nM | 4.59 |
| CHEMBL5407813 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL5395822 | — | IC50 | = | 29370.0 | nM | 4.53 |
| CHEMBL5411043 | — | IC50 | = | 29920.0 | nM | 4.52 |
| CHEMBL5416857 | — | IC50 | = | 31220.0 | nM | 4.51 |
| CHEMBL3134157 | — | IC50 | = | 30720.0 | nM | 4.51 |
| CHEMBL5412115 | — | IC50 | = | 31370.0 | nM | 4.50 |
| CHEMBL5405542 | — | IC50 | = | 32740.0 | nM | 4.49 |
| CHEMBL5397765 | — | IC50 | = | 32890.0 | nM | 4.48 |
| CHEMBL5424312 | — | IC50 | = | 34740.0 | nM | 4.46 |
| CHEMBL5420859 | — | IC50 | = | 37550.0 | nM | 4.42 |
| CHEMBL5409737 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL5407618 | — | IC50 | = | 43330.0 | nM | 4.36 |
| CHEMBL5419612 | — | IC50 | = | 45630.0 | nM | 4.34 |
| CHEMBL5414729 | — | IC50 | = | 47770.0 | nM | 4.32 |
| CHEMBL5433518 | — | IC50 | = | 51360.0 | nM | 4.29 |
| CHEMBL5399307 | — | IC50 | = | 51060.0 | nM | 4.29 |
| CHEMBL5439990 | — | IC50 | = | 68870.0 | nM | 4.16 |
| CHEMBL5421314 | — | IC50 | = | 69450.0 | nM | 4.16 |
| CHEMBL5432322 | — | IC50 | > | 82340.0 | nM | - |
| CHEMBL4574678 | — | IC50 | > | 80250.0 | nM | - |
| CHEMBL5419726 | — | IC50 | > | 100000.0 | nM | - |