Assay Detail
Functional
CHEMBL5366249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MGC-803 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, antitumor activity, and molecular dynamics simulations of novel sphingosine kinase 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.48 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5408050 | — | — | 1 | 4.96 |
| CHEMBL4574678 | — | — | 1 | 4.80 |
| CHEMBL5407736 | — | — | 1 | 4.72 |
| CHEMBL5414729 | — | — | 1 | 4.70 |
| CHEMBL5396922 | — | — | 1 | 4.64 |
| CHEMBL5407813 | — | — | 1 | 4.64 |
| CHEMBL5433518 | — | — | 1 | 4.60 |
| CHEMBL5439990 | — | — | 1 | 4.58 |
| CHEMBL5432767 | — | — | 1 | 4.53 |
| CHEMBL5420859 | — | — | 1 | 4.49 |
| CHEMBL5405542 | — | — | 1 | 4.47 |
| CHEMBL5399307 | — | — | 1 | 4.45 |
| CHEMBL5426621 | — | — | 1 | 4.43 |
| CHEMBL5424312 | — | — | 1 | 4.42 |
| CHEMBL5419726 | — | — | 1 | 4.41 |
| CHEMBL5397765 | — | — | 1 | 4.39 |
| CHEMBL5436330 | — | — | 1 | 4.39 |
| CHEMBL5416857 | — | — | 1 | 4.39 |
| CHEMBL5412115 | — | — | 1 | 4.38 |
| CHEMBL5395822 | — | — | 1 | 4.37 |
| CHEMBL3134157 | — | — | 1 | 4.29 |
| CHEMBL5432322 | — | — | 1 | 4.26 |
| CHEMBL5421314 | — | — | 1 | 4.21 |
| CHEMBL5407618 | — | — | 1 | 4.20 |
| CHEMBL5409737 | — | — | 1 | 4.19 |
| CHEMBL5411043 | — | — | 1 | - |
| CHEMBL5419612 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5408050 | — | IC50 | = | 10920.0 | nM | 4.96 |
| CHEMBL4574678 | — | IC50 | = | 15740.0 | nM | 4.80 |
| CHEMBL5407736 | — | IC50 | = | 19240.0 | nM | 4.72 |
| CHEMBL5414729 | — | IC50 | = | 20170.0 | nM | 4.70 |
| CHEMBL5396922 | — | IC50 | = | 22950.0 | nM | 4.64 |
| CHEMBL5407813 | — | IC50 | = | 22910.0 | nM | 4.64 |
| CHEMBL5433518 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL5439990 | — | IC50 | = | 26060.0 | nM | 4.58 |
| CHEMBL5432767 | — | IC50 | = | 29830.0 | nM | 4.53 |
| CHEMBL5420859 | — | IC50 | = | 32190.0 | nM | 4.49 |
| CHEMBL5405542 | — | IC50 | = | 33750.0 | nM | 4.47 |
| CHEMBL5399307 | — | IC50 | = | 35860.0 | nM | 4.45 |
| CHEMBL5426621 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL5424312 | — | IC50 | = | 37660.0 | nM | 4.42 |
| CHEMBL5419726 | — | IC50 | = | 38640.0 | nM | 4.41 |
| CHEMBL5397765 | — | IC50 | = | 40810.0 | nM | 4.39 |
| CHEMBL5436330 | — | IC50 | = | 40270.0 | nM | 4.39 |
| CHEMBL5416857 | — | IC50 | = | 40550.0 | nM | 4.39 |
| CHEMBL5412115 | — | IC50 | = | 42020.0 | nM | 4.38 |
| CHEMBL5395822 | — | IC50 | = | 42970.0 | nM | 4.37 |
| CHEMBL3134157 | — | IC50 | = | 51660.0 | nM | 4.29 |
| CHEMBL5432322 | — | IC50 | = | 55280.0 | nM | 4.26 |
| CHEMBL5421314 | — | IC50 | = | 61840.0 | nM | 4.21 |
| CHEMBL5407618 | — | IC50 | = | 63550.0 | nM | 4.20 |
| CHEMBL5409737 | — | IC50 | = | 65230.0 | nM | 4.19 |
| CHEMBL5411043 | — | IC50 | > | 79760.0 | nM | - |
| CHEMBL5419612 | — | IC50 | > | 81470.0 | nM | - |