Assay Detail
Binding
CHEMBL5366254
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Inhibition of 5-LOX (unknown orgin) using arachidonic acid as substrate incubated for 10 mins by colorimetric assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure and ligand based design for identification of highly potent molecules against 5-LOX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.49 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404346 | — | — | 1 | 7.52 |
| CHEMBL5431302 | — | — | 1 | 7.16 |
| CHEMBL5403166 | — | — | 1 | 7.00 |
| CHEMBL5401108 | — | — | 1 | 6.60 |
| CHEMBL5414740 | — | — | 1 | 6.58 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.52 |
| CHEMBL5414581 | — | — | 1 | 6.51 |
| CHEMBL5407069 | — | — | 1 | 6.37 |
| CHEMBL5413236 | — | — | 1 | 6.31 |
| CHEMBL5404057 | — | — | 1 | 6.20 |
| CHEMBL5406540 | — | — | 1 | 5.91 |
| CHEMBL5403873 | — | — | 1 | 5.88 |
| CHEMBL5440850 | — | — | 1 | 5.75 |
| CHEMBL5400537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404346 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5431302 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5403166 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5401108 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5414740 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL93 | ZILEUTON | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5414581 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5407069 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5413236 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5404057 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5406540 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL5403873 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL5440850 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL5400537 | — | IC50 | > | 10000.0 | nM | - |