Assay Detail
Functional
CHEMBL5366264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GLP-1 receptor (unknown origin) expressed in CHO cells by cAMP assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.04 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4518483 | DANUGLIPRON | 2.0 | 1 | 8.96 |
| CHEMBL5414345 | — | — | 1 | 8.96 |
| CHEMBL5412337 | — | — | 1 | 8.19 |
| CHEMBL5399466 | — | — | 1 | 8.13 |
| CHEMBL5425925 | — | — | 1 | 7.67 |
| CHEMBL5407549 | — | — | 1 | 7.43 |
| CHEMBL5435749 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4518483 | DANUGLIPRON | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5414345 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5412337 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL5399466 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5425925 | — | EC50 | = | 21.4 | nM | 7.67 |
| CHEMBL5407549 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5435749 | — | EC50 | = | 117.7 | nM | 6.93 |