Assay Detail
Binding
CHEMBL5366266
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-GLP1 from GLP-1 receptor (unknown origin) expressed in CHO cells membrane pre-incubated for 10 mins followed by [125I]-GLP1 addition and measured after 180 mins by microbeta scintillation counting method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.85 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5418836 | — | — | 1 | 8.39 |
| CHEMBL5440900 | — | — | 1 | 8.24 |
| CHEMBL4518483 | DANUGLIPRON | 2.0 | 1 | 7.89 |
| CHEMBL5429544 | — | — | 1 | 7.85 |
| CHEMBL5396298 | — | — | 1 | 7.82 |
| CHEMBL5399359 | — | — | 1 | 7.82 |
| CHEMBL5434776 | — | — | 1 | 7.72 |
| CHEMBL5419346 | — | — | 1 | 7.50 |
| CHEMBL5414345 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5418836 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5440900 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4518483 | DANUGLIPRON | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5429544 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5396298 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5399359 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5434776 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5419346 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5414345 | — | EC50 | = | 35.0 | nM | 7.46 |